Try these costumes for a change! Have fun!
| Costume | How to unlock
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| - Mission Level 1-3 get an SS-rank, or get 10 Medals.
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| - Get all A-rank on all Mission Level (except Level Ex).
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| - Get an S-rank on Mission Level 3-5.
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| - Get S-rank on Mission Level 5-5.
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| - Get all S-rank on all Mission Level (except Level Ex).
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| - Get a B-rank or above for all Mission.
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Clear Mission 4-5 with a B rank.
If you want to use a character's loadout so every other character can use it, score rank A or higher on all missions up to 5-5 with that character.
| Character loadout | How to unlock
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| - Get rank A or higher on all missions up to 5-5 with Wesker.
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| - Get rank A or higher on all missions up to 5-5 with Barry.
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| - Get rank A or higher on all missions up to 5-5 with Chris.
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- Claire Redfield's loadout
| - Get rank A or higher on all missions up to 5-5 with Claire.
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| - Unlock all character loadout.
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| - Get rank A or higher on all missions up to 5-5 with Hunk.
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| - Get rank A or higher on all missions up to 5-5 with Krauser.
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| - Get rank A or higher on all missions up to 5-5 with Jill.
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- Rebecca Chambers's loadout
| - Get rank A or higher on all missions up to 5-5 with Rebecca.
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To make a particular character's weapons accessible to every other characters, score S rank using the character on every Missions up to Mission 5-5. Alternatively, you can spend 10 Nintendo 3DS Play Coins to unlock the character's weapons.
Clear Mission 1-3.
Make sure you have no Green Herbs in your inventory. Find a Green Herb, then pick it up and use it at the same time (press A + Y on the default control scheme). If timed correctly, the game will try to subtract one Green Herb from a total of zero. This will cause the inventory counter to cyclically roll backwards to its maximum amount, resulting in 300 Green Herbs available for use. Note: This will not work online.
Complete mission 5-5 with at "B" or better rank. The EX missions will be available after the credits end.
Clear Mission 4-1 with a B rank.
Clear Mission 3-5.
Complete the indicated task to unlock the corresponding medal.
A Friend in Need: Save your dying partner for the first time in Duo mode.
Beginner: Mission Level 2, complete all missions.
Boom!: Land 100 headshots.
Bright Future: Defeat a parasite with a flash grenade.
Can't Touch This: Complete a mission on or above Mission Level 4 without taking any damage.
Captain: Mission Level 5, complete all missions.
Chicken Hunter Portable: Destroy your first chicken.
Counter Shoot: Shoot down 20 enemy projectiles.
Dead Rising: Kill 53594 enemies.
Dressed to Kill: Unlock all costumes.
Good Combination: Complete a mission with a partner.
Hero: Mission Level EX, complete all missions.
Highly Decorated Medal: Unlock all other medals.
How to Kill: Complete 10 waves in Survival Mission.
In the Buff: Complete a mission with rank A or better on or above Mission Level 4 without using any skills.
Iron Fist: Complete a mission by defeating all enemies with a combo.
Jack of All Trades: Play with all characters.
Leave No Stone Unturned: Play every map more than once.
Let's Work Together: Play Duo mode for the first time.
Like A Phoenix: Recover from Dying status 50 times in Solo.
Master of Unlocking: Unlock all characters.
Me, I Prefer Fists: Crush your enemy with a hand-to hand combat blow after shooting them.
Me, I Prefer Guns: Kill all enemies by gunshot on any mission on or above Mission Level 4.
Meat Shower: Kill 3 enemies with 1 hand grenade.
Mr. Death: Complete 15 waves in Survival Mission.
Newcomer: Mission Level 1, complete all missions.
No Fear: Perform 30 taunts near an enemy.
No Guts, No Glory: Continue 30 times.
No Turning Back: Complete a mission without using the Quick Turn even once.
Now That's Dedication!: Play the game for 14 days straight.
One (Thousand) Down...: Kill 1000 enemies.
Only One: Complete a mission on or above Mission Level 4 using only one of the weapons in your arsenal.
Opening A Dojo: See all of the hand-to-hand combat moves for any one character.
Original Eleven: Complete all missions with SS Rank.
Party Pooper: Blow an enemy up by shooting the dynamite.
Perfect Alliance: Complete any mission with SS Rank with a partner.
Perfection: Complete a mission without ever missing a shot. (100% accuracy rate).
Platoon of Two: Perform 5 Melee attacks in a row during one turn. (Duo only)
Rookie: Mission Level 3, complete all missions.
S.T.A.R.S.: Complete all missions with A Rank or better.
See What You Did There: Set off a Proximity Bomb by shooting it.
Skill Captor: Obtain 15 skills.
Skill Master: Max out all skills (except Infinity 7).
Social Butterfly: Play Duo mode 50 times.
Strike From Behind: Attack an Executioner Majini Black, Red, and Garrador (claw) in their weak point in the back.
Super Combo: Complete a mission on or above Mission Level 4 with a combo amount above 50.
The Old Banana Trick: Cause a running enemy to fall over by shooting.
The Wesker Special: Drop an enemy into magma.
Ultra Combo: Complete a mission on or above Mission Level 4 with a combo amount above 100.
Veteran: Mission Level 4, complete all missions.
Clear Mission 1-3 with a B rank.
Clear Mission 2-3.
Clear Mission 4-2 with a B rank.
To make a character's signature weapons available for all other characters, get an "SS" rank using that character on all missions up to Mission 5-5. Alternately, you can spend 10 Nintendo 3DS Play Coins to unlock a character's weapons.
| Skill | How to unlock
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| - Clear Mission 5-4 with a B rank.
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| - Clear Mission 5-2 with a B rank
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| - Clear Mission Level 4-3 with an S rank.
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| - Clear Mission 4-2 with a S rank.
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| - Clear Mission 4-1 with a S rank.
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| - Obtain "Social Butterfly" Medal.
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| - Clear Mission EX-6 with a B rank.
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| - Clear Mission 4-5 with a S rank.
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| - Clear Mission EX-1 with a B rank.
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| - Clear Mission 4-1 with a B rank.
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| - Clear Mission 5-3 with a B rank.
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| - Clear Mission EX-2 with a B rank.
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| - Clear Mission 4-3 with a B rank.
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| - Clear Mission 5-2 with a S rank.
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| - Clear Mission 4-4 with a B rank.
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| - Clear Mission 1-3 with a B rank.
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| - Clear Mission 4-2 with a B rank.
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| - Clear Mission 5-4 with a S rank.
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| - Clear Mission 5-1 with a B rank.
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| - Clear Mission EX-5 with a B rank.
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| - Clear Mission 5-1 with a S rank.
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| - Clear Mission EX-4 with a B rank.
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| - Clear Mission 5-3 with a S rank.
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| - Earn the Like a Phoenix medal.
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| - Clear Mission EX-8 with a B rank.
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Get an "A" or better rank on all missions up to mission 5-5. You will unlock that particular character's weapon loadout for use by any other character.
Clear Mission 5-5.
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