| Trophy | How to unlock
|
|---|
| - Lose any Story Mode level within 5 seconds.
|
| - Get a combo-pop of 100 or more germs with one shot.
|
- Feverish Cleaning (Bronze)
| - Complete a Story Mode level in under 30 seconds.
|
| - Complete 20 different levels in a single run in Puzzle Mode.
|
| - Complete all Story Mode levels.
|
- Mother of all Pops (Bronze)
| - Pop a germ of size 25x or greater.
|
| - Fire 50 germs in a single Story, Duel, or Arcade level.
|
| - Win the 15th round in a Duel match against "The Germinator".
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| - Complete all Puzzle Mode levels.
|
| - Collect all stars in Puzzle and Story Mode.
|
| - Survive for 5 minutes or more in Arcade Mode.
|
| - Finish any Puzzle level with a single shot.
|
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